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Assessing the impact of differences in malaria transmission intensity on clinical and haematological indices in children with malaria

Overview of attention for article published in Malaria Journal, March 2017
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Title
Assessing the impact of differences in malaria transmission intensity on clinical and haematological indices in children with malaria
Published in
Malaria Journal, March 2017
DOI 10.1186/s12936-017-1745-8
Pubmed ID
Authors

Henrietta E. Mensah-Brown, James Abugri, Kwaku P. Asante, Duah Dwomoh, David Dosoo, Frank Atuguba, David J. Conway, Gordon A. Awandare

Abstract

Malaria control interventions have led to a decline in transmission intensity in many endemic areas, and resulted in elimination in some areas. This decline, however, will lead to delayed acquisition of protective immunity and thus impact disease manifestation and outcomes. Therefore, the variation in clinical and haematological parameters in children with malaria was assessed across three areas in Ghana with varying transmission intensities. A total of 568 children between the ages of 2 and 14 years with confirmed malaria were recruited in hospitals in three areas with varying transmission intensities (Kintampo > Navrongo > Accra) and a comprehensive analysis of parasitological, clinical, haematological and socio-economic parameters was performed. Areas of lower malaria transmission tended to have lower disease severity in children with malaria, characterized by lower parasitaemias and higher haemoglobin levels. In addition, total white cell counts and percent lymphocytes decreased with decreasing transmission intensity. The heterozygous sickle haemoglobin genotype was protective against disease severity in Kintampo (P = 0.016), although this was not significant in Accra and Navrongo. Parasitaemia levels were not a significant predictor of haemoglobin level after controlling for age and gender. However, higher haemoglobin levels in children were associated with certain socioeconomic factors, such as having fathers who had any type of employment (P < 0.05) and mothers who were teachers (P < 0.05). The findings demonstrate significant differences in the haematological presentation and severity of malaria among areas with different transmission intensity in Ghana, indicating that these factors need to be considered in planning the management of the disease as the endemicity is expected to decline after control interventions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 <1%
Unknown 109 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 18%
Researcher 14 13%
Student > Bachelor 12 11%
Student > Postgraduate 7 6%
Lecturer 6 5%
Other 19 17%
Unknown 32 29%
Readers by discipline Count As %
Medicine and Dentistry 16 15%
Nursing and Health Professions 11 10%
Biochemistry, Genetics and Molecular Biology 11 10%
Agricultural and Biological Sciences 8 7%
Social Sciences 8 7%
Other 19 17%
Unknown 37 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2017.
All research outputs
#13,542,613
of 22,957,478 outputs
Outputs from Malaria Journal
#3,542
of 5,587 outputs
Outputs of similar age
#162,455
of 311,244 outputs
Outputs of similar age from Malaria Journal
#74
of 118 outputs
Altmetric has tracked 22,957,478 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,587 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,244 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.