Title |
Evidence of neurodegeneration in autism spectrum disorder
|
---|---|
Published in |
Translational Neurodegeneration, August 2013
|
DOI | 10.1186/2047-9158-2-17 |
Pubmed ID | |
Authors |
Janet K Kern, David A Geier, Lisa K Sykes, Mark R Geier |
Abstract |
Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and abilities. Loss of neurological function in ASD, as observed in affected children who have regressed, can be explained as neurodegeneration. Although there is research evidence of neurodegeneration or progressive encephalopathy in ASD, the issue of neurodegeneration in ASD is still under debate. Evidence of neurodegeneration in the brain in ASD includes: (1) neuronal cell loss, (2) activated microglia and astrocytes, (3) proinflammatory cytokines, (4) oxidative stress, and (5) elevated 8-oxo-guanosine levels. The evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities, and that research into treatments to address the issue of neurodegeneration in ASD are warranted. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 111 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 18% |
Student > Master | 19 | 17% |
Student > Ph. D. Student | 18 | 16% |
Researcher | 12 | 11% |
Student > Doctoral Student | 11 | 10% |
Other | 17 | 15% |
Unknown | 16 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 15% |
Medicine and Dentistry | 15 | 13% |
Psychology | 14 | 12% |
Neuroscience | 13 | 12% |
Biochemistry, Genetics and Molecular Biology | 11 | 10% |
Other | 21 | 19% |
Unknown | 22 | 19% |