Title |
The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion
|
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Published in |
Journal of Neuroinflammation, June 2013
|
DOI | 10.1186/1742-2094-10-75 |
Pubmed ID | |
Authors |
Starlee Lively, Lyanne C Schlichter |
Abstract |
Microglial cells are highly mobile under many circumstances and, after central nervous system (CNS) damage, they must contend with the dense extracellular matrix (ECM) in order to reach their target sites. In response to damage or disease, microglia undergo complex activation processes that can be modulated by environmental cues and culminate in either detrimental or beneficial outcomes. Thus, there is considerable interest in comparing their pro-inflammatory ('classical' activation) and resolving 'alternative' activation states. Almost nothing is known about how these activation states affect the ability of microglia to migrate and degrade ECM, or the enzymes used for substrate degradation. This is the subject of the present study. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
Romania | 1 | <1% |
United States | 1 | <1% |
Serbia | 1 | <1% |
Unknown | 259 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 53 | 20% |
Student > Master | 46 | 17% |
Student > Bachelor | 37 | 14% |
Researcher | 34 | 13% |
Student > Doctoral Student | 27 | 10% |
Other | 32 | 12% |
Unknown | 37 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 61 | 23% |
Agricultural and Biological Sciences | 54 | 20% |
Biochemistry, Genetics and Molecular Biology | 35 | 13% |
Medicine and Dentistry | 24 | 9% |
Engineering | 10 | 4% |
Other | 32 | 12% |
Unknown | 50 | 19% |