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Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

Overview of attention for article published in BMC Pulmonary Medicine, February 2017
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Title
Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients
Published in
BMC Pulmonary Medicine, February 2017
DOI 10.1186/s12890-017-0384-8
Pubmed ID
Authors

Philip J. Lawrence, Umme Kolsum, Vandana Gupta, Gavin Donaldson, Richa Singh, Bethan Barker, Leena George, Adam Webb, Anthony J. Brookes, Christopher Brightling, Jadwiga Wedzicha, Dave Singh

Abstract

The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients in the COPDMAP study were assessed. We aimed to identify the subgroup of patients who progressed to GOLD D (unstable GOLD B patients) and identify characteristics associated with progression. Three hundred seventy COPD patients were assessed at baseline and 12 months thereafter. Demographics, lung function, health status, 6 min walk tests and levels of systemic inflammation were assessed. Students t tests and Mann Whitney-U tests were used. One hundred seven (28.9%) of patients were categorised as GOLD B at baseline. These GOLD B patients had similar FEV1 to GOLD A patients (66% predicted). More GOLD B patients were current smokers (p = 0.031), had chronic bronchitis (p = 0.0003) and cardiovascular comorbidities (p = 0.019) compared to GOLD A. At 12 months, 25.3% of GOLD B patients progressed to GOLD D. These patients who progressed (unstable patients) had worse health status and symptoms (SGRQ-C Total, 50.0 v 41.1, p = 0.019 and CAT, 21.0 v 14.0, p = 0.006) and lower FEV1 (60% v 69% p = 0.014) at baseline compared to stable patients who remained in GOLD B. Unstable GOLD B patients who progressed to GOLD D had a higher level of symptoms at baseline. A high symptom burden may predict an increased likelihood of disease progression in GOLD B patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 19%
Student > Ph. D. Student 4 13%
Student > Bachelor 2 6%
Professor 2 6%
Student > Master 2 6%
Other 3 10%
Unknown 12 39%
Readers by discipline Count As %
Medicine and Dentistry 9 29%
Nursing and Health Professions 2 6%
Unspecified 1 3%
Linguistics 1 3%
Computer Science 1 3%
Other 1 3%
Unknown 16 52%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2017.
All research outputs
#18,536,772
of 22,958,253 outputs
Outputs from BMC Pulmonary Medicine
#1,400
of 1,942 outputs
Outputs of similar age
#237,620
of 310,284 outputs
Outputs of similar age from BMC Pulmonary Medicine
#28
of 29 outputs
Altmetric has tracked 22,958,253 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.