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Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor

Overview of attention for article published in Cell Communication and Signaling, August 2013
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Title
Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor
Published in
Cell Communication and Signaling, August 2013
DOI 10.1186/1478-811x-11-59
Pubmed ID
Authors

Hao Zuo, Grace P W Chan, Jing Zhu, Wendy W S Yeung, Anthony S L Chan, Hermann Ammer, Yung H Wong

Abstract

The FHIT tumor suppressor gene is arguably the most commonly altered gene in cancer since it is inactivated in about 60% of human tumors. The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A. Despite the fact that Fhit functions as a tumor suppressor, the pathway through which Fhit inhibits growth of cancer cells remains largely unknown. Phosphorylation by Src tyrosine kinases provides a linkage between Fhit and growth factor signaling. Since many G proteins can regulate cell proliferation through multiple signaling components including Src, we explored the relationship between Gα subunits and Fhit.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 38%
Student > Ph. D. Student 1 13%
Other 1 13%
Student > Master 1 13%
Professor > Associate Professor 1 13%
Other 0 0%
Unknown 1 13%
Readers by discipline Count As %
Medicine and Dentistry 2 25%
Biochemistry, Genetics and Molecular Biology 1 13%
Computer Science 1 13%
Agricultural and Biological Sciences 1 13%
Neuroscience 1 13%
Other 1 13%
Unknown 1 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2013.
All research outputs
#18,343,746
of 22,716,996 outputs
Outputs from Cell Communication and Signaling
#710
of 979 outputs
Outputs of similar age
#146,474
of 196,016 outputs
Outputs of similar age from Cell Communication and Signaling
#5
of 5 outputs
Altmetric has tracked 22,716,996 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 979 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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