Title |
Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor
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Published in |
Cell Communication and Signaling, August 2013
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DOI | 10.1186/1478-811x-11-59 |
Pubmed ID | |
Authors |
Hao Zuo, Grace P W Chan, Jing Zhu, Wendy W S Yeung, Anthony S L Chan, Hermann Ammer, Yung H Wong |
Abstract |
The FHIT tumor suppressor gene is arguably the most commonly altered gene in cancer since it is inactivated in about 60% of human tumors. The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A. Despite the fact that Fhit functions as a tumor suppressor, the pathway through which Fhit inhibits growth of cancer cells remains largely unknown. Phosphorylation by Src tyrosine kinases provides a linkage between Fhit and growth factor signaling. Since many G proteins can regulate cell proliferation through multiple signaling components including Src, we explored the relationship between Gα subunits and Fhit. |
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