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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system
|
|---|---|
| Published in |
BMC Ecology and Evolution, March 2017
|
| DOI | 10.1186/s12862-017-0904-4 |
| Pubmed ID | |
| Authors |
Sandy Richter, Conrad Helm, Frederic A. Meunier, Lars Hering, Lahcen I. Campbell, Stephan H. Drukewitz, Eivind A. B. Undheim, Ronald A. Jenner, Giampietro Schiavo, Christoph Bleidorn |
| Abstract |
We present the first molecular characterization of glycerotoxin (GLTx), a potent neurotoxin found in the venom of the bloodworm Glycera tridactyla (Glyceridae, Annelida). Within the animal kingdom, GLTx shows a unique mode of action as it can specifically up-regulate the activity of Cav2.2 channels (N-type) in a reversible manner. The lack of sequence information has so far hampered a detailed understanding of its mode of action. Our analyses reveal three ~3.8 kb GLTx full-length transcripts, show that GLTx represents a multigene family, and suggest it functions as a dimer. An integrative approach using transcriptomics, quantitative real-time PCR, in situ hybridization, and immunocytochemistry shows that GLTx is highly expressed exclusively in four pharyngeal lobes, a previously unrecognized part of the venom apparatus. Our results overturn a century old textbook view on the glycerid venom system, suggesting that it is anatomically and functionally much more complex than previously thought. The herein presented GLTx sequence information constitutes an important step towards the establishment of GLTx as a versatile tool to understand the mechanism of synaptic function, as well as the mode of action of this novel neurotoxin. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 19% |
| Germany | 3 | 11% |
| United States | 3 | 11% |
| United Kingdom | 3 | 11% |
| Japan | 2 | 7% |
| Australia | 1 | 4% |
| Italy | 1 | 4% |
| Unknown | 9 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 52% |
| Scientists | 13 | 48% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 31% |
| Student > Master | 6 | 15% |
| Student > Ph. D. Student | 6 | 15% |
| Professor | 2 | 5% |
| Student > Bachelor | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 31% |
| Biochemistry, Genetics and Molecular Biology | 7 | 18% |
| Medicine and Dentistry | 3 | 8% |
| Environmental Science | 2 | 5% |
| Computer Science | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 11 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2017.
All research outputs
#1,252,836
of 25,382,440 outputs
Outputs from BMC Ecology and Evolution
#292
of 3,714 outputs
Outputs of similar age
#24,977
of 323,669 outputs
Outputs of similar age from BMC Ecology and Evolution
#9
of 87 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,669 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.