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Multiple sclerosis: an example of pathogenic viral interaction?

Overview of attention for article published in Virology Journal, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

news
1 news outlet
twitter
7 tweeters

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
96 Mendeley
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Title
Multiple sclerosis: an example of pathogenic viral interaction?
Published in
Virology Journal, February 2017
DOI 10.1186/s12985-017-0719-3
Pubmed ID
Authors

Walter Fierz

Abstract

A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS patients leading to intrathecal B-cell transformation. Consequent T-cell immune response against the EBV-infected cells is postulated as a pathogenic basis for inflammatory lesion formation in the brain of susceptible individuals. A further link between HHV-6A and EBV involves their induction of expression of the human endogenous retrovirus HERV-K18-encoded superantigen. Such virally induced T-cell responses might secondarily also lead to local autoimmune phenomena. Finally, research recommendations are formulated for substantiating the hypothesis on several levels: epidemiologically, genetically, and viral expression in the brain.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 96 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 19%
Student > Bachelor 16 17%
Student > Master 14 15%
Researcher 12 13%
Other 9 9%
Other 11 11%
Unknown 16 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 23%
Medicine and Dentistry 18 19%
Immunology and Microbiology 9 9%
Agricultural and Biological Sciences 7 7%
Neuroscience 7 7%
Other 8 8%
Unknown 25 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2022.
All research outputs
#1,727,423
of 21,796,013 outputs
Outputs from Virology Journal
#125
of 2,940 outputs
Outputs of similar age
#34,831
of 277,852 outputs
Outputs of similar age from Virology Journal
#1
of 1 outputs
Altmetric has tracked 21,796,013 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,940 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,852 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them