Title |
Increased Artemis levels confer radioresistance to both high and low LET radiation exposures
|
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Published in |
Radiation Oncology, June 2012
|
DOI | 10.1186/1748-717x-7-96 |
Pubmed ID | |
Authors |
Deepa M Sridharan, Mary K Whalen, Donna Almendrala, Francis A Cucinotta, Misako Kawahara, Steven M Yannone, Janice M Pluth |
Abstract |
Artemis has a defined role in V(D)J recombination and has been implicated in the repair of radiation induced double-strand breaks. However the exact function(s) of Artemis in DNA repair and its preferred substrate(s) in vivo remain undefined. Our previous work suggests that Artemis is important for the repair of complex DNA damage like that inflicted by high Linear Energy Transfer (LET) radiation. To establish the contribution of Artemis in repairing DNA damage caused by various radiation qualities, we evaluated the effect of over-expressing Artemis on cell survival, DNA repair, and cell cycle arrest after exposure to high and low LET radiation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 29% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 2 | 6% |
Student > Doctoral Student | 2 | 6% |
Student > Bachelor | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 39% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 26% |
Agricultural and Biological Sciences | 7 | 23% |
Medicine and Dentistry | 2 | 6% |
Environmental Science | 1 | 3% |
Neuroscience | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 39% |