Title |
Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
|
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Published in |
BMC Cancer, August 2013
|
DOI | 10.1186/1471-2407-13-391 |
Pubmed ID | |
Authors |
Babu V Sajesh, Zelda Lichtensztejn, Kirk J McManus |
Abstract |
Chromosome instability manifests as an abnormal chromosome complement and is a pathogenic event in cancer. Although a correlation between abnormal chromosome numbers and cancer exist, the underlying mechanisms that cause chromosome instability are poorly understood. Recent data suggests that aberrant sister chromatid cohesion causes chromosome instability and thus contributes to the development of cancer. Cohesion normally functions by tethering nascently synthesized chromatids together to prevent premature segregation and thus chromosome instability. Although the prevalence of aberrant cohesion has been reported for some solid tumors, its prevalence within liquid tumors is unknown. Consequently, the current study was undertaken to evaluate aberrant cohesion within Hodgkin lymphoma, a lymphoid malignancy that frequently exhibits chromosome instability. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 23% |
Student > Ph. D. Student | 8 | 17% |
Researcher | 7 | 15% |
Student > Master | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Other | 4 | 8% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 16 | 33% |
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Medicine and Dentistry | 7 | 15% |
Engineering | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 9 | 19% |