Title |
Genetics of amyotrophic lateral sclerosis: an update
|
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Published in |
Molecular Neurodegeneration, August 2013
|
DOI | 10.1186/1750-1326-8-28 |
Pubmed ID | |
Authors |
Sheng Chen, Pavani Sayana, Xiaojie Zhang, Weidong Le |
Abstract |
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has been done in the past few decades in unveiling the genetics of ALS, successfully identifying at least fifteen candidate genes associated with familial and sporadic ALS. Numerous studies attempting to define the pathogenesis of ALS have identified several plausible determinants and molecular pathways leading to motor neuron degeneration, which include oxidative stress, glutamate excitotoxicity, apoptosis, abnormal neurofilament function, protein misfolding and subsequent aggregation, impairment of RNA processing, defects in axonal transport, changes in endosomal trafficking, increased inflammation, and mitochondrial dysfunction. This review is to update the recent discoveries in genetics of ALS, which may provide insight information to help us better understanding of the disease neuropathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 2 | 67% |
Brazil | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Turkey | 2 | <1% |
Australia | 2 | <1% |
Korea, Republic of | 2 | <1% |
United Kingdom | 2 | <1% |
Uruguay | 1 | <1% |
Spain | 1 | <1% |
Germany | 1 | <1% |
Unknown | 553 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 107 | 19% |
Student > Bachelor | 106 | 19% |
Student > Master | 79 | 14% |
Researcher | 40 | 7% |
Student > Doctoral Student | 32 | 6% |
Other | 73 | 13% |
Unknown | 130 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 107 | 19% |
Biochemistry, Genetics and Molecular Biology | 106 | 19% |
Medicine and Dentistry | 75 | 13% |
Neuroscience | 75 | 13% |
Chemistry | 11 | 2% |
Other | 45 | 8% |
Unknown | 148 | 26% |