Title |
Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island
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Published in |
BMC Cancer, August 2013
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DOI | 10.1186/1471-2407-13-398 |
Pubmed ID | |
Authors |
Reinhold Wasserkort, Alexandra Kalmar, Gabor Valcz, Sandor Spisak, Manuel Krispin, Kinga Toth, Zsolt Tulassay, Andrew Z Sledziewski, Bela Molnar |
Abstract |
The septin 9 gene (SEPT9) codes for a GTP-binding protein associated with filamentous structures and cytoskeleton formation. SEPT9 plays a role in multiple cancers as either an oncogene or a tumor suppressor gene. Regulation of SEPT9 expression is complex and not well understood; however, hypermethylation of the gene was recently introduced as a biomarker for early detection of colorectal cancer (CRC) and has been linked to cancer of the breast and of the head and neck. Because the DNA methylation landscape of different regions of SEPT9 is poorly understood in cancer, we analyzed the methylation patterns of this gene in distinct cell populations from normal and diseased colon mucosa. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | <1% |
United States | 1 | <1% |
Ukraine | 1 | <1% |
Germany | 1 | <1% |
Unknown | 104 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 23 | 21% |
Student > Ph. D. Student | 18 | 17% |
Student > Master | 12 | 11% |
Student > Bachelor | 8 | 7% |
Other | 5 | 5% |
Other | 17 | 16% |
Unknown | 25 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 27 | 25% |
Medicine and Dentistry | 19 | 18% |
Biochemistry, Genetics and Molecular Biology | 17 | 16% |
Unspecified | 3 | 3% |
Nursing and Health Professions | 3 | 3% |
Other | 12 | 11% |
Unknown | 27 | 25% |