Title |
The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling
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Published in |
BMC Genomics, August 2013
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DOI | 10.1186/1471-2164-14-575 |
Pubmed ID | |
Authors |
Yuqi He, Lei Gong, Yaping Fang, Qi Zhan, Hui-Xin Liu, Yanliu Lu, Grace L Guo, Lois Lehman-McKeeman, Jianwen Fang, Yu-Jui Yvonne Wan |
Abstract |
The eyes and skin are obvious retinoid target organs. Vitamin A deficiency causes night blindness and retinoids are widely used to treat acne and psoriasis. However, more than 90% of total body retinol is stored in liver stellate cells. In addition, hepatocytes produce the largest amount of retinol binding protein and cellular retinoic acid binding protein to mobilize retinol from the hepatic storage pool and deliver retinol to its receptors, respectively. Furthermore, hepatocytes express the highest amount of retinoid x receptor alpha (RXRα) among all the cell types. Surprisingly, the function of endogenous retinoids in the liver has received very little attention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 17% |
Student > Ph. D. Student | 9 | 15% |
Researcher | 7 | 12% |
Student > Bachelor | 5 | 8% |
Other | 5 | 8% |
Other | 11 | 18% |
Unknown | 13 | 22% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Medicine and Dentistry | 12 | 20% |
Agricultural and Biological Sciences | 7 | 12% |
Immunology and Microbiology | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 6 | 10% |
Unknown | 15 | 25% |