Title |
Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
|
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Published in |
Respiratory Research, October 2009
|
DOI | 10.1186/1465-9921-10-102 |
Pubmed ID | |
Authors |
Michael CW Chan, Renee WY Chan, Wendy CL Yu, Carol CC Ho, WH Chui, CK Lo, Kit M Yuen, Yi Guan, John M Nicholls, JS Malik Peiris |
Abstract |
Highly pathogenic avian influenza (HPAI) H5N1 virus is entrenched in poultry in Asia and Africa and continues to infect humans zoonotically causing acute respiratory disease syndrome and death. There is evidence that the virus may sometimes spread beyond respiratory tract to cause disseminated infection. The primary target cell for HPAI H5N1 virus in human lung is the alveolar epithelial cell. Alveolar epithelium and its adjacent lung microvascular endothelium form host barriers to the initiation of infection and dissemination of influenza H5N1 infection in humans. These are polarized cells and the polarity of influenza virus entry and egress as well as the secretion of cytokines and chemokines from the virus infected cells are likely to be central to the pathogenesis of human H5N1 disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 4% |
United Kingdom | 2 | 2% |
Belgium | 1 | 1% |
China | 1 | 1% |
Denmark | 1 | 1% |
Unknown | 81 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 28% |
Student > Ph. D. Student | 20 | 22% |
Student > Master | 11 | 12% |
Student > Bachelor | 11 | 12% |
Other | 5 | 6% |
Other | 14 | 16% |
Unknown | 4 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 42% |
Immunology and Microbiology | 16 | 18% |
Medicine and Dentistry | 15 | 17% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Veterinary Science and Veterinary Medicine | 2 | 2% |
Other | 9 | 10% |
Unknown | 5 | 6% |