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Current progress in dengue vaccines

Overview of attention for article published in Journal of Biomedical Science, June 2013
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Title
Current progress in dengue vaccines
Published in
Journal of Biomedical Science, June 2013
DOI 10.1186/1423-0127-20-37
Pubmed ID
Authors

Shu-Wen Wan, Chiou-Feng Lin, Shuying Wang, Yu-Hung Chen, Trai-Ming Yeh, Hsiao-Sheng Liu, Robert Anderson, Yee-Shin Lin

Abstract

Dengue is one of the most important emerging vector-borne viral diseases. There are four serotypes of dengue viruses (DENV), each of which is capable of causing self-limited dengue fever (DF) or even life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The major clinical manifestations of severe DENV disease are vascular leakage, thrombocytopenia, and hemorrhage, yet the detailed mechanisms are not fully resolved. Besides the direct effects of the virus, immunopathological aspects are also involved in the development of dengue symptoms. Although no licensed dengue vaccine is yet available, several vaccine candidates are under development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, and live recombinant, DNA and subunit vaccines. The live attenuated virus vaccines and live chimeric virus vaccines are undergoing clinical evaluation. The other vaccine candidates have been evaluated in preclinical animal models or are being prepared for clinical trials. For the safety and efficacy of dengue vaccines, the immunopathogenic complications such as antibody-mediated enhancement and autoimmunity of dengue disease need to be considered.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 4 2%
Indonesia 2 <1%
Malaysia 1 <1%
Unknown 232 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 53 22%
Student > Bachelor 47 20%
Student > Ph. D. Student 35 15%
Researcher 27 11%
Student > Doctoral Student 14 6%
Other 36 15%
Unknown 27 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 75 31%
Medicine and Dentistry 54 23%
Biochemistry, Genetics and Molecular Biology 26 11%
Immunology and Microbiology 14 6%
Computer Science 7 3%
Other 30 13%
Unknown 33 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2013.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Journal of Biomedical Science
#839
of 1,101 outputs
Outputs of similar age
#152,702
of 209,499 outputs
Outputs of similar age from Journal of Biomedical Science
#6
of 9 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,499 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.