Title |
Estrogenic and mutagenic activities of Crotalaria pallida measured by recombinant yeast assay and Ames test
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Published in |
BMC Complementary Medicine and Therapies, September 2013
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DOI | 10.1186/1472-6882-13-216 |
Pubmed ID | |
Authors |
Paula Karina Boldrin, Flávia Aparecida Resende, Ana Paula Oliveira Höhne, Mariana Santoro de Camargo, Lívia Greghi Espanha, Catarine Haidê Nogueira, Maria do Socorro F Melo, Wagner Vilegas, Eliana Aparecida Varanda |
Abstract |
Crotalaria pallida Ailton is a plant belonging to the Fabaceae family, popularly known as "rattle or rattlesnake" and used in traditional medicine to treat swelling of the joints and as a vermifuge. Previous pharmacological studies have also reported anti-inflammatory, antimicrobial and antifungal activities. Nevertheless, scientific information regarding this species is scarce, and there are no reports related to its possible estrogenic and mutagenic effects. Thus, the purpose of the present study was to investigate the estrogenic potential of C. pallida leaves by means of the Recombinant Yeast Assay (RYA), seeking an alternative for estrogen replacement therapy during menopause; and to reflect on the safe use of natural products to assess the mutagenic activity of the crude extract from C. pallida leaves, the dichloromethane fraction and stigmasterol by means of the Ames test. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 26% |
Student > Ph. D. Student | 5 | 12% |
Researcher | 3 | 7% |
Professor | 3 | 7% |
Lecturer | 2 | 5% |
Other | 6 | 14% |
Unknown | 12 | 29% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 7 | 17% |
Chemistry | 5 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Environmental Science | 3 | 7% |
Other | 5 | 12% |
Unknown | 13 | 31% |