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Estrogenic and mutagenic activities of Crotalaria pallida measured by recombinant yeast assay and Ames test

Overview of attention for article published in BMC Complementary Medicine and Therapies, September 2013
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Title
Estrogenic and mutagenic activities of Crotalaria pallida measured by recombinant yeast assay and Ames test
Published in
BMC Complementary Medicine and Therapies, September 2013
DOI 10.1186/1472-6882-13-216
Pubmed ID
Authors

Paula Karina Boldrin, Flávia Aparecida Resende, Ana Paula Oliveira Höhne, Mariana Santoro de Camargo, Lívia Greghi Espanha, Catarine Haidê Nogueira, Maria do Socorro F Melo, Wagner Vilegas, Eliana Aparecida Varanda

Abstract

Crotalaria pallida Ailton is a plant belonging to the Fabaceae family, popularly known as "rattle or rattlesnake" and used in traditional medicine to treat swelling of the joints and as a vermifuge. Previous pharmacological studies have also reported anti-inflammatory, antimicrobial and antifungal activities. Nevertheless, scientific information regarding this species is scarce, and there are no reports related to its possible estrogenic and mutagenic effects. Thus, the purpose of the present study was to investigate the estrogenic potential of C. pallida leaves by means of the Recombinant Yeast Assay (RYA), seeking an alternative for estrogen replacement therapy during menopause; and to reflect on the safe use of natural products to assess the mutagenic activity of the crude extract from C. pallida leaves, the dichloromethane fraction and stigmasterol by means of the Ames test.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 26%
Student > Ph. D. Student 5 12%
Researcher 3 7%
Professor 3 7%
Lecturer 2 5%
Other 6 14%
Unknown 12 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 17%
Chemistry 5 12%
Biochemistry, Genetics and Molecular Biology 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Environmental Science 3 7%
Other 5 12%
Unknown 13 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2013.
All research outputs
#17,695,202
of 22,719,618 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,333
of 3,620 outputs
Outputs of similar age
#140,756
of 196,871 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#56
of 79 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,620 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,871 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.