Title |
Ontology based molecular signatures for immune cell types via gene expression analysis
|
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Published in |
BMC Bioinformatics, August 2013
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DOI | 10.1186/1471-2105-14-263 |
Pubmed ID | |
Authors |
Terrence F Meehan, Nicole A Vasilevsky, Christopher J Mungall, David S Dougall, Melissa A Haendel, Judith A Blake, Alexander D Diehl |
Abstract |
New technologies are focusing on characterizing cell types to better understand their heterogeneity. With large volumes of cellular data being generated, innovative methods are needed to structure the resulting data analyses. Here, we describe an 'Ontologically BAsed Molecular Signature' (OBAMS) method that identifies novel cellular biomarkers and infers biological functions as characteristics of particular cell types. This method finds molecular signatures for immune cell types based on mapping biological samples to the Cell Ontology (CL) and navigating the space of all possible pairwise comparisons between cell types to find genes whose expression is core to a particular cell type's identity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 5 | 8% |
Netherlands | 2 | 3% |
Japan | 1 | 2% |
Ireland | 1 | 2% |
Unknown | 56 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 22 | 34% |
Student > Ph. D. Student | 12 | 18% |
Other | 4 | 6% |
Professor > Associate Professor | 4 | 6% |
Student > Master | 4 | 6% |
Other | 12 | 18% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 32% |
Biochemistry, Genetics and Molecular Biology | 20 | 31% |
Computer Science | 5 | 8% |
Medicine and Dentistry | 4 | 6% |
Engineering | 3 | 5% |
Other | 4 | 6% |
Unknown | 8 | 12% |