Title |
Stereotactic prostate adaptive radiotherapy utilising kilovoltage intrafraction monitoring: the TROG 15.01 SPARK trial
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Published in |
BMC Cancer, March 2017
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DOI | 10.1186/s12885-017-3164-1 |
Pubmed ID | |
Authors |
Paul Keall, Doan Trang Nguyen, Ricky O’Brien, Jeremy Booth, Peter Greer, Per Poulsen, Val Gebski, Andrew Kneebone, Jarad Martin |
Abstract |
This paper describes the multi-institutional prospective phase II clinical trial, SPARK: Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage Intrafraction Monitoring (KIM). KIM is a real-time image guided radiotherapy technology being developed and clinically pioneered for prostate cancer treatment in Australia. It has potential for widespread use for target radiotherapy treatment of cancers of the pelvis, thorax and abdomen. In the SPARK trial we will measure the cancer targeting accuracy and patient outcomes for 48 prostate cancer patients who will be treated in five treatment sessions as opposed to the conventional 40 sessions. The reduced number of treatment sessions is enabled by the KIM's increased cancer targeting accuracy. Real-time imaging in radiotherapy has the potential to decrease the time taken during cancer treatment and reduce the imaging dose required. With the imaging being acquired during the treatment, and the analysis being automated, there is potential for improved throughput. The SPARK trial will be conducted under the auspices of the Trans-Tasman Radiation Oncology Group (TROG). This trial was registered on ClinicalTrials.gov on 09 March 2015. The identifier is: NCT02397317. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 23% |
Researcher | 4 | 9% |
Lecturer | 3 | 7% |
Student > Master | 3 | 7% |
Student > Doctoral Student | 3 | 7% |
Other | 11 | 25% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 36% |
Physics and Astronomy | 10 | 23% |
Nursing and Health Professions | 2 | 5% |
Environmental Science | 1 | 2% |
Psychology | 1 | 2% |
Other | 3 | 7% |
Unknown | 11 | 25% |