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The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota

Overview of attention for article published in BMC Biology, September 2013
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Title
The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota
Published in
BMC Biology, September 2013
DOI 10.1186/1741-7007-11-99
Pubmed ID
Authors

Widad Dantoft, Monica M Davis, Jessica M Lindvall, Xiongzhuo Tang, Hanna Uvell, Anna Junell, Anne Beskow, Ylva Engström

Abstract

Innate immune responses are evolutionarily conserved processes that provide crucial protection against invading organisms. Gene activation by potent NF-κB transcription factors is essential both in mammals and Drosophila during infection and stress challenges. If not strictly controlled, this potent defense system can activate autoimmune and inflammatory stress reactions, with deleterious consequences for the organism. Negative regulation to prevent gene activation in healthy organisms, in the presence of the commensal gut flora, is however not well understood.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 23%
Researcher 15 20%
Student > Master 9 12%
Student > Bachelor 6 8%
Professor 4 5%
Other 13 17%
Unknown 11 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 37%
Biochemistry, Genetics and Molecular Biology 14 19%
Immunology and Microbiology 12 16%
Medicine and Dentistry 5 7%
Computer Science 1 1%
Other 2 3%
Unknown 13 17%