Title |
Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain
|
---|---|
Published in |
Immunity & Ageing, September 2013
|
DOI | 10.1186/1742-4933-10-38 |
Pubmed ID | |
Authors |
Marie-Paule Vasson, Marie-Chantal Farges, Nicolas Goncalves-Mendes, Jérémie Talvas, Josep Ribalta, Brigitte Winklhofer-Roob, Edmond Rock, Adrien Rossary |
Abstract |
As the European population is getting older, there is growing need in scientific data on how to achieve healthy and successful aging. A decline in immune function with age is unanimously supported by many epidemiological and clinical observations, with a decrease in T-cell mediated function encompassing a large part of this alteration. In the EU-funded VITAGE project, the effects of aging on biomarkers of immune status are being studied in three European countries. According to strict inclusion/exclusion criteria, a cohort of 300 healthy male non-smoking 20-75 years old volunteers were enrolled in France (n = 99), Spain (n = 100) and Austria (n = 101). In each country, the volunteers were classified as a function of age (one age group per decade). Biomarkers of immune status were determined including delayed-type hypersensitivity tests, measurement of lymphocyte surface markers, and serum determinations of interleukin-2, complement fractions and immunoglobulins. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 20% |
Spain | 1 | 20% |
Singapore | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 80% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Sudan | 1 | 2% |
Argentina | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 18% |
Researcher | 8 | 14% |
Student > Master | 7 | 12% |
Student > Ph. D. Student | 6 | 11% |
Professor > Associate Professor | 5 | 9% |
Other | 12 | 21% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 16% |
Agricultural and Biological Sciences | 9 | 16% |
Immunology and Microbiology | 8 | 14% |
Nursing and Health Professions | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 8 | 14% |
Unknown | 15 | 26% |