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Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne

Overview of attention for article published in BMC Dermatology, September 2013
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Title
Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne
Published in
BMC Dermatology, September 2013
DOI 10.1186/1471-5945-13-10
Pubmed ID
Authors

Joanne Louise Selway, Tomasz Kurczab, Terence Kealey, Kenneth Langlands

Abstract

Acne is a common disorder of the human pilosebaceous unit, yet the mechanisms underlying hyperkeratinisation and subsequent inflammation (comedogenesis) remain to be determined, although cutaneous pathogens are implicated. Previously, it was reported that the release of the cytokine interleukin-1α (IL-1α) by keratinocytes of the sebaceous duct was pivotal in the life cycle of the comedone, mediating both its development and its spontaneous resolution. Toll-like receptors are a family of molecules that recognise pathogen associated molecular patterns (PAMPs) presented by microorganisms, initiating a signalling cascade terminating in the release of antimicrobial compounds and cytokines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Italy 1 1%
Egypt 1 1%
Unknown 91 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 18%
Student > Master 13 14%
Other 12 13%
Student > Bachelor 9 10%
Student > Ph. D. Student 9 10%
Other 15 16%
Unknown 19 20%
Readers by discipline Count As %
Medicine and Dentistry 25 27%
Agricultural and Biological Sciences 22 23%
Biochemistry, Genetics and Molecular Biology 10 11%
Immunology and Microbiology 5 5%
Chemistry 4 4%
Other 7 7%
Unknown 21 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2013.
All research outputs
#15,278,165
of 22,719,618 outputs
Outputs from BMC Dermatology
#87
of 133 outputs
Outputs of similar age
#121,102
of 197,012 outputs
Outputs of similar age from BMC Dermatology
#2
of 2 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 133 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,012 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.