Title |
Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne
|
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Published in |
BMC Dermatology, September 2013
|
DOI | 10.1186/1471-5945-13-10 |
Pubmed ID | |
Authors |
Joanne Louise Selway, Tomasz Kurczab, Terence Kealey, Kenneth Langlands |
Abstract |
Acne is a common disorder of the human pilosebaceous unit, yet the mechanisms underlying hyperkeratinisation and subsequent inflammation (comedogenesis) remain to be determined, although cutaneous pathogens are implicated. Previously, it was reported that the release of the cytokine interleukin-1α (IL-1α) by keratinocytes of the sebaceous duct was pivotal in the life cycle of the comedone, mediating both its development and its spontaneous resolution. Toll-like receptors are a family of molecules that recognise pathogen associated molecular patterns (PAMPs) presented by microorganisms, initiating a signalling cascade terminating in the release of antimicrobial compounds and cytokines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 1% |
Italy | 1 | 1% |
Egypt | 1 | 1% |
Unknown | 91 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 18% |
Student > Master | 13 | 14% |
Other | 12 | 13% |
Student > Bachelor | 9 | 10% |
Student > Ph. D. Student | 9 | 10% |
Other | 15 | 16% |
Unknown | 19 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 27% |
Agricultural and Biological Sciences | 22 | 23% |
Biochemistry, Genetics and Molecular Biology | 10 | 11% |
Immunology and Microbiology | 5 | 5% |
Chemistry | 4 | 4% |
Other | 7 | 7% |
Unknown | 21 | 22% |