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Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series

Overview of attention for article published in Journal of Biomedical Science, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#27 of 997)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
5 news outlets
twitter
1 tweeter

Citations

dimensions_citation
119 Dimensions

Readers on

mendeley
291 Mendeley
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Title
Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series
Published in
Journal of Biomedical Science, February 2017
DOI 10.1186/s12929-017-0324-1
Pubmed ID
Authors

Manish Suthar, Saniya Gupta, Suhail Bukhari, Venkatesh Ponemone

Abstract

Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. PRP is a conglomeration of thrombocytes, cytokines and various growth factors which are secreted by α-granules of platelets that augment the rate of natural healing process with decrease in time. The purpose of this case series was to evaluate the safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers on the lower extremity. Autologous PRP was prepared from whole blood utilizing a rapid, intraoperative point-of-care system that works on the principle of density gradient centrifugation. Twenty Four (24) patients with non-healing ulcers of different etiologies, who met the inclusion criteria, were treated with single dose of subcutaneous PRP injections along with topical application of PRP gel under compassionate use. The mean age of the treated patients was 62.5 ± 13.53 years and they were followed-up for a period of 24 weeks. All the patients showed signs of wound healing with reduction in wound size, and the mean time duration to ulcer healing was 8.2 weeks. Also, an average five fold increase in the platelet concentrate was observed in the final PRP product obtained using the rapid point-of-care device, and the average platelet dose administered to the patients was 70.10 × 10(8). This case series has demonstrated the potential safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers. NCT03026855 , Registered 4 January 2017 'Retrospectively'.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 291 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 291 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 46 16%
Student > Master 33 11%
Researcher 26 9%
Other 23 8%
Student > Postgraduate 18 6%
Other 57 20%
Unknown 88 30%
Readers by discipline Count As %
Medicine and Dentistry 88 30%
Nursing and Health Professions 29 10%
Biochemistry, Genetics and Molecular Biology 26 9%
Agricultural and Biological Sciences 13 4%
Pharmacology, Toxicology and Pharmaceutical Science 9 3%
Other 32 11%
Unknown 94 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2017.
All research outputs
#832,467
of 22,959,818 outputs
Outputs from Journal of Biomedical Science
#27
of 997 outputs
Outputs of similar age
#19,130
of 312,052 outputs
Outputs of similar age from Journal of Biomedical Science
#3
of 15 outputs
Altmetric has tracked 22,959,818 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 997 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.