Title |
Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
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Published in |
Respiratory Research, March 2017
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DOI | 10.1186/s12931-017-0534-9 |
Pubmed ID | |
Authors |
Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, Leif Bjermer, Hans Jürgen Hoffmann, Jonas S. Erjefält, Martin R. Stampfli |
Abstract |
Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 17% |
Researcher | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Other | 1 | 3% |
Other | 4 | 13% |
Unknown | 10 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 27% |
Nursing and Health Professions | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 3 | 10% |
Unknown | 12 | 40% |