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Home treatment in paediatric patients with Hunter syndrome: the first Italian experience

Overview of attention for article published in Italian Journal of Pediatrics, September 2013
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Title
Home treatment in paediatric patients with Hunter syndrome: the first Italian experience
Published in
Italian Journal of Pediatrics, September 2013
DOI 10.1186/1824-7288-39-53
Pubmed ID
Authors

Ferdinando Ceravolo, Italia Mascaro, Simona Sestito, Elisa Pascale, Antonino Lauricella, Elio Dizione, Daniela Concolino

Abstract

Hunter syndrome (mucopolysaccharidosis type II [MPS II], OMIM309900) is a rare X-linked lysosomal storage disorder caused by the deficiency of the enzyme iduronate-2-sulphatase, resulting in accumulation of glycosaminoglycans, progressive multisystem organ failure, and early death. Enzyme replacement therapy (ERT) with weekly intravenous infusions of idursulfase, a treatment for MPS II and commercially available since 2007, has been shown to improve certain symptoms and signs of the disease. The efficacy and safety data of this enzyme preparation have been widely reported and, after a change to the idursulfase Summary of Product Characteristics in March 2010, home ERT by infusion is now an option for selected patients. Previously reported experiences of home therapy in MPS II have shown increased treatment compliance and an improvement in quality of life for both patients and families. We report the results of the home therapy experience of 3 paediatric patients with MPS II in southern Italy. This pilot experience with home infusion is the first reported from Italy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 17%
Student > Master 7 15%
Other 5 10%
Unspecified 5 10%
Student > Doctoral Student 4 8%
Other 7 15%
Unknown 12 25%
Readers by discipline Count As %
Medicine and Dentistry 10 21%
Unspecified 5 10%
Nursing and Health Professions 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 10 21%
Unknown 16 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2013.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Italian Journal of Pediatrics
#574
of 1,059 outputs
Outputs of similar age
#132,036
of 210,415 outputs
Outputs of similar age from Italian Journal of Pediatrics
#10
of 18 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,059 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,415 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.