Title |
MC1Rgenotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study
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Published in |
BMC Cancer, September 2013
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DOI | 10.1186/1471-2407-13-406 |
Pubmed ID | |
Authors |
Anne E Cust, Chris Goumas, Kylie Vuong, John R Davies, Jennifer H Barrett, Elizabeth A Holland, Helen Schmid, Chantelle Agha-Hamilton, Bruce K Armstrong, Richard F Kefford, Joanne F Aitken, Graham G Giles, D Timothy Bishop, Julia A Newton-Bishop, John L Hopper, Graham J Mann, Mark A Jenkins |
Abstract |
Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribution to melanoma risk prediction compared with traditional risk factors is unknown. We aimed to 1) evaluate the separate and incremental contribution of MC1R genotype to prediction of early-onset melanoma, and compare this with the contributions of physician-measured and self-reported traditional risk factors, and 2) develop risk prediction models that include MC1R, and externally validate these models using an independent dataset from a genetically similar melanoma population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 16% |
Student > Ph. D. Student | 6 | 13% |
Student > Bachelor | 6 | 13% |
Student > Postgraduate | 4 | 9% |
Student > Master | 4 | 9% |
Other | 11 | 24% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 36% |
Agricultural and Biological Sciences | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Neuroscience | 2 | 4% |
Other | 5 | 11% |
Unknown | 9 | 20% |