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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency
|
|---|---|
| Published in |
Breast Cancer Research, September 2013
|
| DOI | 10.1186/bcr3471 |
| Pubmed ID | |
| Authors |
Rachel L Atkinson, Wei T Yang, Daniel G Rosen, Melissa D Landis, Helen Wong, Michael T Lewis, Chad J Creighton, Krystal R Sexton, Sue G Hilsenbeck, Aysegul A Sahin, Abenaa M Brewster, Wendy A Woodward, Jenny C Chang |
| Abstract |
We hypothesized that cells present in normal tissue that bear cancer stem cell markers may represent a cancer cell of origin or a microenvironment primed for tumor development, and that their presence may correlate with the clinically defined subtypes of breast cancer that show increased tumorigenicity and stem cell features. methods: Normal tissues sampled at least 5 cm from primary tumors (normal adjacent tissue) were obtained from 61 chemotherapy-naive patients with breast cancer treated with mastectomy. Samples were stained simultaneously with immunofluorescence for CD44/CD49f/CD133/2 stem cell markers. We assessed the association between CD44+CD49f+CD133/2+ staining in normal adjacent tissue and breast cancer receptor subtype (defined by the expression of the estrogen (ER), progesterone (PR), or human epidermal growth factor-2 (Her2) receptors). We also examined the correlation between CD44+CD49f+CD133/2+ immunofluorescence and each of two previously published gene signatures, one derived from stem-cell enriched tissue and one from BRCA mutated tissue expected to have defective DNA repair. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Chile | 1 | <1% |
| Norway | 1 | <1% |
| India | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 112 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 23% |
| Student > Ph. D. Student | 23 | 20% |
| Student > Bachelor | 11 | 9% |
| Student > Master | 11 | 9% |
| Other | 6 | 5% |
| Other | 21 | 18% |
| Unknown | 18 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 38% |
| Medicine and Dentistry | 26 | 22% |
| Biochemistry, Genetics and Molecular Biology | 12 | 10% |
| Nursing and Health Professions | 3 | 3% |
| Business, Management and Accounting | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 19 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2013.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Breast Cancer Research
#1,706
of 2,052 outputs
Outputs of similar age
#157,838
of 209,008 outputs
Outputs of similar age from Breast Cancer Research
#22
of 28 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,008 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.