Title |
Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma
|
---|---|
Published in |
Clinical Epigenetics, September 2013
|
DOI | 10.1186/1868-7083-5-16 |
Pubmed ID | |
Authors |
Christopher J Ricketts, Mark R Morris, Dean Gentle, Salwati Shuib, Michael Brown, Noel Clarke, Wenbin Wei, Paul Nathan, Farida Latif, Eamonn R Maher |
Abstract |
Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation of the VHL tumour suppressor gene (TSG), inactivation of chromosome 3p TSGs implicated in chromatin modification and remodelling and de novo tumour-specific promoter methylation of renal TSGs. In the light of these observations it can be proposed that, as in some haematological malignancies, demethylating agents such as azacitidine might be beneficial for the treatment of advanced RCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 31% |
North Macedonia | 1 | 8% |
Chile | 1 | 8% |
France | 1 | 8% |
Canada | 1 | 8% |
Unknown | 5 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 62% |
Scientists | 2 | 15% |
Science communicators (journalists, bloggers, editors) | 2 | 15% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 23% |
Researcher | 6 | 15% |
Student > Master | 5 | 13% |
Student > Bachelor | 3 | 8% |
Professor | 2 | 5% |
Other | 9 | 23% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 31% |
Agricultural and Biological Sciences | 11 | 28% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Environmental Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 8% |
Unknown | 4 | 10% |