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Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

Overview of attention for article published in Clinical Epigenetics, September 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

blogs
1 blog
twitter
13 X users
patent
1 patent

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
39 Mendeley
citeulike
1 CiteULike
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Title
Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma
Published in
Clinical Epigenetics, September 2013
DOI 10.1186/1868-7083-5-16
Pubmed ID
Authors

Christopher J Ricketts, Mark R Morris, Dean Gentle, Salwati Shuib, Michael Brown, Noel Clarke, Wenbin Wei, Paul Nathan, Farida Latif, Eamonn R Maher

Abstract

Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation of the VHL tumour suppressor gene (TSG), inactivation of chromosome 3p TSGs implicated in chromatin modification and remodelling and de novo tumour-specific promoter methylation of renal TSGs. In the light of these observations it can be proposed that, as in some haematological malignancies, demethylating agents such as azacitidine might be beneficial for the treatment of advanced RCC.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Researcher 6 15%
Student > Master 5 13%
Student > Bachelor 3 8%
Professor 2 5%
Other 9 23%
Unknown 5 13%
Readers by discipline Count As %
Medicine and Dentistry 12 31%
Agricultural and Biological Sciences 11 28%
Biochemistry, Genetics and Molecular Biology 7 18%
Environmental Science 1 3%
Nursing and Health Professions 1 3%
Other 3 8%
Unknown 4 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2023.
All research outputs
#2,085,451
of 24,892,887 outputs
Outputs from Clinical Epigenetics
#121
of 1,415 outputs
Outputs of similar age
#17,923
of 203,718 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 7 outputs
Altmetric has tracked 24,892,887 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,415 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them