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Inflammatory myofibroblastic tumor with RANBP2 and ALKgene rearrangement: a report of two cases and literature review

Overview of attention for article published in Diagnostic Pathology, September 2013
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Title
Inflammatory myofibroblastic tumor with RANBP2 and ALKgene rearrangement: a report of two cases and literature review
Published in
Diagnostic Pathology, September 2013
DOI 10.1186/1746-1596-8-147
Pubmed ID
Authors

Jian Li, Wei-hua Yin, Kengo Takeuchi, Hong Guan, Yu-hua Huang, John KC Chan

Abstract

Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (RANBP2) and anaplastic lymphoma kinase (ALK) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. However, fewer than 10 cases of IMT-RA have been reported to date. Herein, we present 2 new cases of IMT-RA in which both tumors recurred quickly after primary surgery; one patient died 3 months later from the disease, and the other patient has been living with the disease for 12 months. IMT-RAs are characterized by noncohesive epithelioid and rounded tumoral cell morphology, commonly derived from pelvic and peritoneal cavities, and frequently show larger tumor sizes. The relation between the clinicopathologic features and poor prognosis of IMT-RA is discussed.

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Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 17%
Student > Bachelor 3 13%
Student > Postgraduate 3 13%
Student > Master 3 13%
Student > Ph. D. Student 2 9%
Other 6 26%
Unknown 2 9%
Readers by discipline Count As %
Medicine and Dentistry 8 35%
Biochemistry, Genetics and Molecular Biology 2 9%
Sports and Recreations 2 9%
Mathematics 1 4%
Agricultural and Biological Sciences 1 4%
Other 4 17%
Unknown 5 22%