Title |
Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system
|
---|---|
Published in |
Molecular Brain, September 2013
|
DOI | 10.1186/1756-6606-6-40 |
Pubmed ID | |
Authors |
Jonathan Liu, Jeanne M Sisk, Lucio Gama, Janice E Clements, Kenneth W Witwer |
Abstract |
The RNA-binding protein tristetraprolin (TTP) participates in normal post-transcriptional control of cytokine and chemokine gene expression, dysregulation of which contributes to the HIV-associated neurocognitive disorders. Transcriptional and post-transcriptional regulation of TTP has been described, including regulation by microRNA-29a. In the simian immunodeficiency virus (SIV) model of HIV CNS disease, control of cytokine/chemokine expression coincides with the end of acute phase infection. This control is lost during progression to disease. In this study, we assessed TTP regulation and association with cytokine regulation in the brain during SIV infection. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 21% |
Student > Ph. D. Student | 6 | 18% |
Researcher | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Other | 5 | 15% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 15% |
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Immunology and Microbiology | 2 | 6% |
Other | 4 | 12% |
Unknown | 7 | 21% |