Title |
Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol
|
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Published in |
Allergy, Asthma & Clinical Immunology, September 2013
|
DOI | 10.1186/1710-1492-9-35 |
Pubmed ID | |
Authors |
Giovanni A Zurzolo, Katrina J Allen, Steve L Taylor, Wayne G Shreffler, Joseph L Baumert, Mimi L K Tang, Lyle C Gurrin, Michael L Mathai, Julie A Nordlee, Audrey DunnGalvin, Jonathan O’B Hourihane |
Abstract |
The eliciting dose (ED) for a peanut allergic reaction in 5% of the peanut allergic population, the ED05, is 1.5 mg of peanut protein. This ED05 was derived from oral food challenges (OFC) that use graded, incremental doses administered at fixed time intervals. Individual patients' threshold doses were used to generate population dose-distribution curves using probability distributions from which the ED05 was then determined. It is important to clinically validate that this dose is predictive of the allergenic response in a further unselected group of peanut-allergic individuals. |
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United States | 4 | 25% |
Netherlands | 1 | 6% |
Canada | 1 | 6% |
Mexico | 1 | 6% |
Romania | 1 | 6% |
Unknown | 2 | 13% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 11 | 69% |
Scientists | 3 | 19% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
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United States | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 17% |
Researcher | 12 | 17% |
Other | 7 | 10% |
Student > Master | 7 | 10% |
Student > Bachelor | 4 | 6% |
Other | 12 | 17% |
Unknown | 15 | 22% |
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Chemistry | 5 | 7% |
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Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 9 | 13% |
Unknown | 16 | 23% |