Title |
Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitrousage of alternative coreceptors during progressive HIV-1 subtype C infection
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Published in |
Retrovirology, September 2013
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DOI | 10.1186/1742-4690-10-98 |
Pubmed ID | |
Authors |
Kieran Cashin, Martin R Jakobsen, Jasminka Sterjovski, Michael Roche, Anne Ellett, Jacqueline K Flynn, Katharina Borm, Maelenn Gouillou, Melissa J Churchill, Paul R Gorry |
Abstract |
Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is spreading rapidly and is now responsible for >50% of HIV-1 infections worldwide, and >95% of infections in southern Africa and central Asia. These regions are burdened with the overwhelming majority of HIV-1 infections, yet we know very little about the pathogenesis of C-HIV. In addition to CCR5 and CXCR4, the HIV-1 envelope glycoproteins (Env) may engage a variety of alternative coreceptors for entry into transfected cells. Whilst alternative coreceptors do not appear to have a broad role in mediating the entry of HIV-1 into primary cells, characterizing patterns of alternative coreceptor usage in vitro can provide valuable insights into mechanisms of Env-coreceptor engagement that may be important for HIV-1 pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 26% |
Researcher | 9 | 23% |
Student > Ph. D. Student | 7 | 18% |
Student > Postgraduate | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 4 | 10% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 31% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Immunology and Microbiology | 6 | 15% |
Medicine and Dentistry | 6 | 15% |
Computer Science | 2 | 5% |
Other | 2 | 5% |
Unknown | 4 | 10% |