Title |
Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques
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Published in |
Retrovirology, September 2013
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DOI | 10.1186/1742-4690-10-99 |
Pubmed ID | |
Authors |
Konstantin Virnik, Max Hockenbury, Yisheng Ni, Joel Beren, George N Pavlakis, Barbara K Felber, Ira Berkower |
Abstract |
Live attenuated viruses are among our most potent and effective vaccines. For human immunodeficiency virus, however, a live attenuated strain could present substantial safety concerns. We have used the live attenuated rubella vaccine strain RA27/3 as a vector to express SIV and HIV vaccine antigens because its safety and immunogenicity have been demonstrated in millions of children. One dose protects for life against rubella infection. In previous studies, rubella vectors replicated to high titers in cell culture while stably expressing SIV and HIV antigens. Their viability in vivo, however, as well as immunogenicity and antibody persistence, were unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 19% |
Student > Postgraduate | 3 | 14% |
Student > Master | 3 | 14% |
Student > Bachelor | 2 | 10% |
Professor | 2 | 10% |
Other | 4 | 19% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 38% |
Immunology and Microbiology | 5 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Business, Management and Accounting | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 10% |