Title |
Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors
|
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Published in |
Journal of Translational Medicine, September 2013
|
DOI | 10.1186/1479-5876-11-213 |
Pubmed ID | |
Authors |
Jacqueline D Peacock, David Cherba, Kevin Kampfschulte, Mallory K Smith, Noel R Monks, Craig P Webb, Matthew Steensma |
Abstract |
Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A overexpression in these tumors, doxorubicin resistance is common, and the mechanisms of chemotherapy resistance in MPNST are poorly understood. Molecular-guided therapy prediction is an emerging strategy for treatment refractory sarcomas that involves identification of therapy response and resistance mechanisms in individual tumors. Here, we report the results from a personalized, molecular-guided therapy analysis of MPNST samples. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 24% |
Student > Ph. D. Student | 5 | 20% |
Student > Doctoral Student | 3 | 12% |
Student > Master | 2 | 8% |
Student > Bachelor | 1 | 4% |
Other | 3 | 12% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 40% |
Agricultural and Biological Sciences | 6 | 24% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Psychology | 1 | 4% |
Other | 1 | 4% |
Unknown | 4 | 16% |