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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells
|
|---|---|
| Published in |
Journal of Ovarian Research, April 2013
|
| DOI | 10.1186/1757-2215-6-25 |
| Pubmed ID | |
| Authors |
Matthew J Schultz, Amanda F Swindall, John W Wright, Elizabeth S Sztul, Charles N Landen, Susan L Bellis |
| Abstract |
Platinum drugs, including cisplatin, are a frontline therapeutic in ovarian cancer treatment and acquired resistance to these agents is a major contributor to ovarian cancer morbidity and mortality. In this study a novel glycosylation-dependent mechanism for cisplatin resistance is described. Specifically, cisplatin-induced cell death is blocked by the activity of the ST6Gal-I sialyltransferase. ST6Gal-I modifies specific receptors by adding a negatively charged sialic acid sugar which influences diverse receptor functions. Overexpression of ST6Gal-I is a hallmark of ovarian and other cancers and its expression has been correlated to metastasis and poor prognosis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Central African Republic | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 58 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 18% |
| Researcher | 11 | 18% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 7 | 12% |
| Student > Doctoral Student | 5 | 8% |
| Other | 7 | 12% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 22% |
| Medicine and Dentistry | 10 | 17% |
| Agricultural and Biological Sciences | 10 | 17% |
| Chemistry | 7 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 12 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2013.
All research outputs
#18,347,414
of 22,721,584 outputs
Outputs from Journal of Ovarian Research
#312
of 582 outputs
Outputs of similar age
#151,129
of 199,507 outputs
Outputs of similar age from Journal of Ovarian Research
#3
of 5 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 582 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,507 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.