Title |
The unique evolution of the programmed cell death 4 protein in plants
|
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Published in |
BMC Ecology and Evolution, September 2013
|
DOI | 10.1186/1471-2148-13-199 |
Pubmed ID | |
Authors |
Shijun Cheng, Renyi Liu, Daniel R Gallie |
Abstract |
The programmed cell death 4 (PDCD4) protein is induced in animals during apoptosis and functions to inhibit translation and tumor promoter-induced neoplastic transformation. PDCD4 is composed of two MA3 domains that share similarity with the single MA3 domain present in the eukaryotic translation initiation factor (eIF) 4G, which serves as a scaffold protein to assemble several initiation factors needed for the recruitment of the 40S ribosomal subunit to an mRNA. Although eIF4A is an ATP-dependent RNA helicase that binds the MA3 domain of eIF4G to promote translation initiation, binding of eIF4A to the MA3 domains of PDCD4 inhibits protein synthesis. Genes encoding PDCD4 are present in many lower eukaryotes and in plants, but PDCD4 in higher plants is unique in that it contains four MA3 domains and has been implicated in ethylene signaling and abiotic stress responses. Here, we examine the evolution of PDCD4 in plants. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 36% |
Researcher | 6 | 21% |
Student > Bachelor | 3 | 11% |
Student > Master | 3 | 11% |
Student > Doctoral Student | 1 | 4% |
Other | 3 | 11% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 61% |
Biochemistry, Genetics and Molecular Biology | 7 | 25% |
Earth and Planetary Sciences | 1 | 4% |
Unknown | 3 | 11% |