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Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum

Overview of attention for article published in BMC Complementary Medicine and Therapies, September 2013
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Title
Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum
Published in
BMC Complementary Medicine and Therapies, September 2013
DOI 10.1186/1472-6882-13-229
Pubmed ID
Authors

Tamires Aparecida Bitencourt, Tatiana Takahasi Komoto, Bruna Gabriele Massaroto, Carlos Eduardo Saraiva Miranda, Rene Oliveira Beleboni, Mozart Marins, Ana Lúcia Fachin

Abstract

Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton rubrum and their effects on fatty acid and ergosterol synthesis.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Unknown 70 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 20%
Student > Ph. D. Student 12 17%
Student > Bachelor 8 11%
Student > Doctoral Student 6 8%
Researcher 3 4%
Other 5 7%
Unknown 23 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 15%
Biochemistry, Genetics and Molecular Biology 10 14%
Chemistry 7 10%
Pharmacology, Toxicology and Pharmaceutical Science 7 10%
Immunology and Microbiology 2 3%
Other 7 10%
Unknown 27 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2013.
All research outputs
#18,347,414
of 22,721,584 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,498
of 3,620 outputs
Outputs of similar age
#150,160
of 201,942 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#63
of 86 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,620 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,942 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.