Title |
Structural and functional insights into Mimivirus ORFans
|
---|---|
Published in |
BMC Genomics, May 2007
|
DOI | 10.1186/1471-2164-8-115 |
Pubmed ID | |
Authors |
Harpreet Kaur Saini, Daniel Fischer |
Abstract |
Mimivirus isolated from A. polyphaga is the largest virus discovered so far. It is unique among all the viruses in having genes related to translation, DNA repair and replication which bear close homology to eukaryotic genes. Nevertheless, only a small fraction of the proteins (33%) encoded in this genome has been assigned a function. Furthermore, a large fraction of the unassigned protein sequences bear no sequence similarity to proteins from other genomes. These sequences are referred to as ORFans. Because of their lack of sequence similarity to other proteins, they can not be assigned putative functions using standard sequence comparison methods. As part of our genome-wide computational efforts aimed at characterizing Mimivirus ORFans, we have applied fold-recognition methods to predict the structure of these ORFans and further functions were derived based on conservation of functionally important residues in sequence-template alignments. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 4% |
Portugal | 1 | 2% |
Germany | 1 | 2% |
Colombia | 1 | 2% |
France | 1 | 2% |
United States | 1 | 2% |
Unknown | 38 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 24% |
Researcher | 10 | 22% |
Student > Master | 6 | 13% |
Student > Bachelor | 3 | 7% |
Student > Doctoral Student | 2 | 4% |
Other | 5 | 11% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 64% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Unspecified | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Social Sciences | 1 | 2% |
Other | 2 | 4% |
Unknown | 8 | 18% |