Title |
HIV latency and integration site placement in five cell-based models
|
---|---|
Published in |
Retrovirology, August 2013
|
DOI | 10.1186/1742-4690-10-90 |
Pubmed ID | |
Authors |
Scott Sherrill-Mix, Mary K Lewinski, Marylinda Famiglietti, Alberto Bosque, Nirav Malani, Karen E Ocwieja, Charles C Berry, David Looney, Liang Shan, Luis M Agosto, Matthew J Pace, Robert F Siliciano, Una O’Doherty, John Guatelli, Vicente Planelles, Frederic D Bushman |
Abstract |
HIV infection can be treated effectively with antiretroviral agents, but the persistence of a latent reservoir of integrated proviruses prevents eradication of HIV from infected individuals. The chromosomal environment of integrated proviruses has been proposed to influence HIV latency, but the determinants of transcriptional repression have not been fully clarified, and it is unclear whether the same molecular mechanisms drive latency in different cell culture models. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
United Kingdom | 1 | <1% |
Denmark | 1 | <1% |
Germany | 1 | <1% |
Unknown | 151 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 25% |
Researcher | 35 | 22% |
Student > Bachelor | 17 | 11% |
Student > Master | 14 | 9% |
Professor | 9 | 6% |
Other | 18 | 12% |
Unknown | 24 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 31% |
Biochemistry, Genetics and Molecular Biology | 33 | 21% |
Medicine and Dentistry | 23 | 15% |
Immunology and Microbiology | 14 | 9% |
Engineering | 3 | 2% |
Other | 9 | 6% |
Unknown | 26 | 17% |