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Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2

Overview of attention for article published in Virology Journal, August 2013
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Title
Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2
Published in
Virology Journal, August 2013
DOI 10.1186/1743-422x-10-250
Pubmed ID
Authors

Xiaojun Li, Peihu Fan, Jun Jin, Weiheng Su, Dong An, Lin Xu, Shiyang Sun, Yan Zhang, Xiangyu Meng, Feng Gao, Wei Kong, Chunlai Jiang

Abstract

Human enterovirus type 71 (EV71) and Coxsackievirus A group type 16 (CA16) belong to human Enterovirus species A of the family Picornaviridae. These viruses are recognized as the major pathogens responsible for epidemics of hand-foot-mouth disease (HFMD), which presents with fever and vesicular eruptions of palms, soles of the feet or mouth. Human scavenger receptor class B, member 2 (SCARB2) has been identified as the receptor for both EV71 and CA16, as overexpression of SCARB2 in cells can enhance virus replication significantly.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 22%
Researcher 5 16%
Student > Master 5 16%
Student > Ph. D. Student 4 13%
Student > Doctoral Student 3 9%
Other 2 6%
Unknown 6 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 16%
Agricultural and Biological Sciences 5 16%
Immunology and Microbiology 4 13%
Medicine and Dentistry 3 9%
Nursing and Health Professions 2 6%
Other 5 16%
Unknown 8 25%