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The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage

Overview of attention for article published in Arthritis Research & Therapy, July 2013
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Title
The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage
Published in
Arthritis Research & Therapy, July 2013
DOI 10.1186/ar4178
Pubmed ID
Authors

Anne Tuskey, David Peura

Abstract

Pain affects the quality of life for millions of individuals and is a major reason for healthcare utilization. As populations age, medical personnel will need to manage more and more patients suffering from pain associated with degenerative and inflammatory musculoskeletal disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are an effective treatment for both acute and chronic musculoskeletal pain; however, their use is associated with potentially significant gastrointestinal (GI) toxicity. Guidelines suggest various strategies to prevent problems in those at risk for NSAID-associated GI complications. In this article, we review the data supporting one such strategy - the use of histamine type-2 receptor antagonists (H2RAs) - for the prevention of GI adverse events in NSAID users. Older studies suggest that high-dose H2RAs are effective in preventing upper GI ulcers and dyspepsia. This suggestion was recently confirmed during clinical trials with a new ibuprofen/famotidine combination that reduced the risk of ulcers by 50% compared with ibuprofen alone.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Australia 1 1%
Unknown 77 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 23 29%
Student > Master 15 19%
Researcher 5 6%
Student > Postgraduate 5 6%
Student > Ph. D. Student 3 4%
Other 5 6%
Unknown 23 29%
Readers by discipline Count As %
Medicine and Dentistry 32 41%
Pharmacology, Toxicology and Pharmaceutical Science 13 16%
Agricultural and Biological Sciences 5 6%
Nursing and Health Professions 2 3%
Psychology 2 3%
Other 2 3%
Unknown 23 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2022.
All research outputs
#20,233,045
of 25,728,855 outputs
Outputs from Arthritis Research & Therapy
#2,840
of 3,411 outputs
Outputs of similar age
#153,921
of 210,408 outputs
Outputs of similar age from Arthritis Research & Therapy
#27
of 34 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,411 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,408 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.