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Mendeley readers
| Title |
Biological function of Presenilin and its role in AD pathogenesis
|
|---|---|
| Published in |
Translational Neurodegeneration, July 2013
|
| DOI | 10.1186/2047-9158-2-15 |
| Pubmed ID | |
| Authors |
Shuting Zhang, Mingming Zhang, Fang Cai, Weihong Song |
| Abstract |
Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components - presenilins and their biological functions and contributions to the AD pathogenesis. The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones. The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch; the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway, regulating calcium homeostasis and their interaction with synaptic transmission. |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| France | 1 | <1% |
| Norway | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 140 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 20% |
| Student > Bachelor | 27 | 18% |
| Student > Master | 20 | 14% |
| Researcher | 16 | 11% |
| Student > Doctoral Student | 5 | 3% |
| Other | 16 | 11% |
| Unknown | 33 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 23% |
| Agricultural and Biological Sciences | 22 | 15% |
| Neuroscience | 18 | 12% |
| Medicine and Dentistry | 10 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 17 | 12% |
| Unknown | 40 | 27% |