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Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

Overview of attention for article published in Acta Neuropathologica Communications, July 2013
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  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

patent
1 patent

Citations

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85 Dimensions

Readers on

mendeley
166 Mendeley
citeulike
1 CiteULike
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Title
Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments
Published in
Acta Neuropathologica Communications, July 2013
DOI 10.1186/2051-5960-1-34
Pubmed ID
Authors

Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson, Charles A Hoeffer

Abstract

Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal dementia (FTD) and Alzheimer's disease (AD). Tauopathies are also associated with deficits in synaptic plasticity such as long-term potentiation (LTP), but the specific role of tau in the manifestation of these deficiencies is not well-understood. We examined long lasting forms of synaptic plasticity in JNPL3 (BL6) mice expressing mutant tau that is identified in some inherited FTDs.

Mendeley readers

The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Korea, Republic of 1 <1%
Russia 1 <1%
Unknown 162 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 19%
Researcher 24 14%
Student > Bachelor 23 14%
Student > Doctoral Student 17 10%
Student > Master 15 9%
Other 28 17%
Unknown 27 16%
Readers by discipline Count As %
Neuroscience 48 29%
Agricultural and Biological Sciences 37 22%
Medicine and Dentistry 16 10%
Psychology 8 5%
Biochemistry, Genetics and Molecular Biology 8 5%
Other 12 7%
Unknown 37 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2017.
All research outputs
#7,432,447
of 22,721,584 outputs
Outputs from Acta Neuropathologica Communications
#950
of 1,368 outputs
Outputs of similar age
#64,925
of 194,306 outputs
Outputs of similar age from Acta Neuropathologica Communications
#9
of 28 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,306 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.