Title |
Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments
|
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Published in |
Acta Neuropathologica Communications, July 2013
|
DOI | 10.1186/2051-5960-1-34 |
Pubmed ID | |
Authors |
Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson, Charles A Hoeffer |
Abstract |
Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal dementia (FTD) and Alzheimer's disease (AD). Tauopathies are also associated with deficits in synaptic plasticity such as long-term potentiation (LTP), but the specific role of tau in the manifestation of these deficiencies is not well-understood. We examined long lasting forms of synaptic plasticity in JNPL3 (BL6) mice expressing mutant tau that is identified in some inherited FTDs. |
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Demographic breakdown
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Student > Doctoral Student | 17 | 10% |
Student > Master | 15 | 8% |
Other | 30 | 17% |
Unknown | 34 | 19% |
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Psychology | 9 | 5% |
Biochemistry, Genetics and Molecular Biology | 8 | 4% |
Other | 11 | 6% |
Unknown | 44 | 25% |