Title |
Calorie restriction and cancer prevention: a mechanistic perspective
|
---|---|
Published in |
Cancer & Metabolism, March 2013
|
DOI | 10.1186/2049-3002-1-10 |
Pubmed ID | |
Authors |
Stephen D Hursting, Sarah M Dunlap, Nikki A Ford, Marcie J Hursting, Laura M Lashinger |
Abstract |
Calorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned from research on CR to cancer prevention strategies in human beings is important given the high prevalence of excess energy intake, obesity, and metabolic syndrome in many parts of the world and the established links between obesity-associated metabolic perturbations and increased risk or progression of many types of cancer. This review synthesizes findings on the biological mechanisms underlying many of the anticancer effects of CR, with emphasis on the impact of CR on growth factor signaling pathways, inflammation, cellular and systemic energy homeostasis pathways, vascular perturbations, and the tumor microenvironment. These CR-responsive pathways and processes represent targets for translating CR research into effective cancer prevention strategies in human beings. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
Saudi Arabia | 1 | 13% |
Venezuela, Bolivarian Republic of | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Scientists | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Pakistan | 1 | <1% |
Sweden | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 172 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 27 | 15% |
Student > Ph. D. Student | 26 | 15% |
Student > Master | 26 | 15% |
Researcher | 20 | 11% |
Other | 14 | 8% |
Other | 33 | 19% |
Unknown | 32 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 43 | 24% |
Medicine and Dentistry | 39 | 22% |
Biochemistry, Genetics and Molecular Biology | 30 | 17% |
Nursing and Health Professions | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Other | 14 | 8% |
Unknown | 42 | 24% |