Title |
Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats
|
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Published in |
Lipids in Health and Disease, September 2013
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DOI | 10.1186/1476-511x-12-136 |
Pubmed ID | |
Authors |
Uberdan Guilherme Mendes de Castro, Robson Augusto Souza Augusto Souza dos Santos, Marcelo Eustáquio Silva, Wanderson Geraldo de Lima, Maria José Campagnole-Santos, Andréia Carvalho Alzamora |
Abstract |
The metabolic syndrome (MS) is characterized by variable coexistence of metabolic and pathophysiological alterations which are important risk factors for developing of type II diabetes and/or cardiovascular diseases. Increased of MS patients in worldwide has stimulated the development of experimental models. However, it is still challenging to find an dietetic model that most closely approximates human MS and, in addition, is not yet fully established the effect of different diets of MS in lipid metabolism in rats of different ages. The aim of this study was to evaluate the effect of different diets of MS in lipid metabolism and ectopic fat deposition and define the most appropriate diet for inducing the characteristic disturbances of the human MS in rats of different ages. |
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