Title |
Altered inflammatory responsiveness in serotonin transporter mutant rats
|
---|---|
Published in |
Journal of Neuroinflammation, September 2013
|
DOI | 10.1186/1742-2094-10-116 |
Pubmed ID | |
Authors |
Flavia Macchi, Judith R Homberg, Francesca Calabrese, Claudia Zecchillo, Giorgio Racagni, Marco A Riva, Raffaella Molteni |
Abstract |
Growing evidence suggests that alterations of the inflammatory/immune system contribute to the pathogenesis of depression. Indeed, depressed patients exhibit increased levels of inflammatory markers in both the periphery and the brain, and high comorbidity exists between major depression and diseases associated with inflammatory alterations. In order to characterize the link between depression and inflammation, we aimed to investigate whether an altered inflammatory system is present in a genetic model of vulnerability for depression, namely rats with partial or total deletion of the serotonin transporter (SERT) gene. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 67 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 25% |
Student > Ph. D. Student | 13 | 19% |
Student > Master | 8 | 12% |
Student > Bachelor | 6 | 9% |
Professor > Associate Professor | 4 | 6% |
Other | 4 | 6% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 23% |
Neuroscience | 9 | 13% |
Medicine and Dentistry | 8 | 12% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 5 | 7% |
Unknown | 24 | 35% |