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Gene expression modifications in Wharton’s Jelly mesenchymal stem cells promoted by prolonged in vitro culturing

Overview of attention for article published in BMC Genomics, September 2013
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Title
Gene expression modifications in Wharton’s Jelly mesenchymal stem cells promoted by prolonged in vitro culturing
Published in
BMC Genomics, September 2013
DOI 10.1186/1471-2164-14-635
Pubmed ID
Authors

Valentina Gatta, Marco D’Aurora, Paola Lanuti, Laura Pierdomenico, Samantha Sperduti, Giandomenico Palka, Marco Gesi, Marco Marchisio, Sebastiano Miscia, Liborio Stuppia

Abstract

It has been demonstrated that the umbilical cord matrix, represented by the Wharton's Jelly (WJ), contains a great number of mesenchymal stem cells (MSCs), characterized by the expression of specific MSCs markers, shared by both human and animal models. The easy access to massive WJ amount makes it an attractive source of MSCs for cell-based therapies. However, as in other stem cell models, a deeper investigation of WJ-derived MSCs (WJ-MSCs) biological properties, probably modulated by their prolonged expansion and fast growth abilities, is required before their use in clinical settings. In this context, in order to analyze specific gene expression modifications occurring in WJ-MSCs, along with their culture prolongation, we investigated the transcriptomic profiles of WJ-MSCs after 4 and 12 passages of in vitro expansion by microarray analysis.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
France 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 21%
Researcher 8 17%
Student > Ph. D. Student 6 13%
Student > Bachelor 4 9%
Student > Doctoral Student 3 6%
Other 8 17%
Unknown 8 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 30%
Biochemistry, Genetics and Molecular Biology 9 19%
Medicine and Dentistry 8 17%
Psychology 2 4%
Materials Science 2 4%
Other 2 4%
Unknown 10 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2013.
All research outputs
#18,348,542
of 22,723,682 outputs
Outputs from BMC Genomics
#8,156
of 10,626 outputs
Outputs of similar age
#150,333
of 202,141 outputs
Outputs of similar age from BMC Genomics
#92
of 145 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,626 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,141 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.