Title |
A rational treatment of Mendelian genetics
|
---|---|
Published in |
Theoretical Biology and Medical Modelling, August 2004
|
DOI | 10.1186/1742-4682-1-6 |
Pubmed ID | |
Authors |
John W Porteous |
Abstract |
The key to a rational treatment of elementary Mendelian genetics, specifically to an understanding of the origin of dominant and recessive traits, lies in the facts that: (1) alleles of genes encode polypeptides; (2) most polypeptides are catalysts, i.e. enzymes or translocators; (3) the molecular components of all traits in all cells are the products of systems of enzymes, i.e. of fluxing metabolic pathways; (4) any flux to the molecular components of a trait responds non-linearly (non-additively) to graded mutations in the activity of any one of the enzymes at a catalytic locus in a metabolic system; (5) as the flux responds to graded changes in the activity of an enzyme, the concentrations of the molecular components of a trait also change. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 27% |
Professor | 3 | 27% |
Lecturer | 2 | 18% |
Student > Ph. D. Student | 1 | 9% |
Unspecified | 1 | 9% |
Other | 0 | 0% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 64% |
Chemical Engineering | 1 | 9% |
Environmental Science | 1 | 9% |
Unspecified | 1 | 9% |
Unknown | 1 | 9% |