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“Non-canonical protein-DNA interactions identified by ChIP are not artifacts”: response

Overview of attention for article published in BMC Genomics, September 2013
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Title
“Non-canonical protein-DNA interactions identified by ChIP are not artifacts”: response
Published in
BMC Genomics, September 2013
DOI 10.1186/1471-2164-14-638
Pubmed ID
Authors

Daniel Schindler, Torsten Waldminghaus

Abstract

Studies of protein association with DNA on a genome wide scale are possible through methods like ChIP-Chip or ChIP-Seq. Massive problems with false positive signals in our own experiments motivated us to revise the standard ChIP-Chip protocol. Analysis of chromosome wide binding of the alternative sigma factor σ³² in Escherichia coli with this new protocol resulted in detection of only a subset of binding sites found in a previous study by Wade and colleagues. We suggested that the remainder of binding sites detected in the previous study are likely to be false positives. In a recent article the Wade group claimed that our conclusion is wrong and that the disputed sites are genuine σ³² binding sites. They further claimed that the non-detection of these sites in our study was due to low data quality.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 40%
Researcher 3 12%
Student > Bachelor 2 8%
Student > Doctoral Student 2 8%
Professor > Associate Professor 2 8%
Other 3 12%
Unknown 3 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 36%
Agricultural and Biological Sciences 9 36%
Immunology and Microbiology 3 12%
Unknown 4 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2014.
All research outputs
#16,722,190
of 25,374,647 outputs
Outputs from BMC Genomics
#6,569
of 11,244 outputs
Outputs of similar age
#129,276
of 214,044 outputs
Outputs of similar age from BMC Genomics
#95
of 207 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,044 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 207 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.