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Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants

Overview of attention for article published in Virology Journal, September 2013
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Title
Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants
Published in
Virology Journal, September 2013
DOI 10.1186/1743-422x-10-292
Pubmed ID
Authors

Mingshun Zhang, Guohong Ge, Yonglin Yang, Xubing Cai, Qiang Fu, Jie Cai, Zuhu Huang

Abstract

Selective pressure from either the immune response or the use of nucleoside analogs in antiviral therapy could be driving the emergence of HBV mutants. Because of the overlap of the open reading frame (ORF) S for the HBsAg and ORF P for viral polymerase, rtM204I and rtM204V mutations in the polymerase would produce sI195M and sW196S in the HBsAg. The combined effects of immune-escaped mutations (sT118M, sG145K, sG145R) and drug-resistant mutations (rtM204I, rtM204V) on the antigenicity profiles of HBsAg has not been widely explored.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 42%
Researcher 2 17%
Student > Ph. D. Student 2 17%
Lecturer 1 8%
Other 1 8%
Other 0 0%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Biochemistry, Genetics and Molecular Biology 3 25%
Immunology and Microbiology 2 17%
Agricultural and Biological Sciences 2 17%
Unknown 1 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2013.
All research outputs
#18,348,542
of 22,723,682 outputs
Outputs from Virology Journal
#2,427
of 3,035 outputs
Outputs of similar age
#150,489
of 202,286 outputs
Outputs of similar age from Virology Journal
#57
of 64 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,286 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.