Title |
CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice
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Published in |
Molecular Brain, September 2013
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DOI | 10.1186/1756-6606-6-41 |
Pubmed ID | |
Authors |
Shirin Akther, Natalia Korshnova, Jing Zhong, Mingkun Liang, Stanislav M Cherepanov, Olga Lopatina, Yulia K Komleva, Alla B Salmina, Tomoko Nishimura, Azam AKM Fakhrul, Hirokazu Hirai, Ichiro Kato, Yasuhiko Yamamoto, Shin Takasawa, Hiroshi Okamoto, Haruhiro Higashida |
Abstract |
Mammalian sires participate in infant care. We previously demonstrated that sires of a strain of nonmonogamous laboratory mice initiate parental retrieval behavior in response to olfactory and auditory signals from the dam during isolation in a new environment. This behavior is rapidly lost in the absence of such signals when the sires are caged alone. The neural circuitry and hormones that control paternal behavior are not well-understood. CD38, a membrane glycoprotein, catalyzes synthesis of cyclic ADP-ribose and facilitates oxytocin (OT) secretion due to cyclic ADP-ribose-dependent increases in cytosolic free calcium concentrations in oxytocinergic neurons in the hypothalamus. In this paper, we studied CD38 in the nucleus accumbens (NAcc) and the role of OT on paternal pup retrieval behavior using CD38 knockout (CD38-/-) mice of the ICR strain. |
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