Title |
Lymphocytic infiltration in the cutaneous lymphoma microenvironment after injection of TG1042
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Published in |
Journal of Translational Medicine, September 2013
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DOI | 10.1186/1479-5876-11-226 |
Pubmed ID | |
Authors |
Nathalie Accart, Mirjana Urosevic-Maiwald, Reinhard Dummer, Vincent Bataille, Nadine Kehrer, Cristina Niculescu, Jean-Marc Limacher, Marie-Pierre Chenard, Jean-Yves Bonnefoy, Ronald Rooke |
Abstract |
Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalance the Th2-immunosuppressive state associated with this pathology. In a phase I/II clinical trial, we correlated the local immune infiltrate and the anti-tumor effects of repeated intralesional administrations of an adenovirus vector expressing human interferon-gamma (IFN-g) termed TG1042, in patients with advanced primary cutaneous T-cell lymphomas (CTCL) or multilesional cutaneous B-cell lymphomas (CBCL). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 33% |
Student > Master | 3 | 14% |
Other | 2 | 10% |
Student > Ph. D. Student | 1 | 5% |
Lecturer | 1 | 5% |
Other | 2 | 10% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 38% |
Agricultural and Biological Sciences | 4 | 19% |
Immunology and Microbiology | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Unknown | 5 | 24% |